ABSTRACT
The objective of the study is to compare the maternal side effects and complications of Misoprostol and prostaglandin F2alpha for termination of second trimester pregnancy. Non randomized controlled [Experimental] study. This comparative study was carried out in Gynae Unit 1, Lady Willingdon Hospital Lahore from 1[st] Oct 2009 to 31[st] Mar 2010. Sixty patients admitted to gynecology ward for termination of pregnancy through the outpatient department were selected according to inclusion criteria of the study. They were divided into two groups of 30 patients each. Group 1 was given Misoprostol and group 2 PGF2alpha for induction of labour. Induction failure was higher in PGF2alpha group. Side effects were more frequent in the women receiving PGF2a than those receiving Misoprostol [56.67% vs. 43.33%; p=0.96]; diarrhea [26.67% vs. 20%] and fever [16.67% vs. 10%]. Incidence of nausea and vomiting were 6.67% in both the groups. In the same way, the complication of post partum hemorrhage was seen more in PGF2a group than the Misoprostol group [6.67% vs. 3.33%]. The incidence of retained placentas was 6.67% in both the groups. The average cost per treatment was Rs. 619 for PGF2a as compared with Rs. 135 for Misoprostol. Misoprostol is cost effective has fewer complications and side effects as compared to PGF2alpha
Subject(s)
Humans , Female , Misoprostol , Misoprostol/adverse effects , Dinoprost , Dinoprost/adverse effects , Administration, Intravaginal , Pregnancy Trimester, Second/drug effects , Diarrhea , Fever , Postoperative Nausea and Vomiting , Postpartum Hemorrhage , Placenta, Retained , Cost-Benefit AnalysisABSTRACT
To compare the efficacy and complications of Misoprostal and Prostaglandin F[2] alpha for Second Trimester Pregnancy termination. Sixty pregnancy women at 14-24 weeks of gestation divided into two group A and B. Group-A Misoprostal, Group-B Prostaglandin F[2]alpha. Patients needing terminations of pregnancy were 10%. The mean induction expulsion interval found in Group-A 19.13 hours and in Group-B 20.07 hours. The complication in Misoprostal group like dead fetus, pelvic infection, coagulopathy, rupture, incomplete abortion were less as compare to PGF[2] alpha group. Misoprostal is more effective then PGF[2] alpha for second trimester pregnancy terminations
Subject(s)
Humans , Female , Misoprostol/adverse effects , Dinoprost , Dinoprost/adverse effects , Abortion, Therapeutic , Pregnancy Trimester, Second , Fetal Death , Abortion, Incomplete , Pelvic InfectionABSTRACT
To evaluate the safety of extra-amniotic PGF2a in induced 2nd trimester abortion in patient with caesarean scar.2] To find out induction abortion interval. A retrospective study. Obstetrics and Gynaecology Department Unit-I, Allied Hospital, Faisalabad from 01-01-2002 to 31-122005. fifty patients with previous uterine scar were selected for 2nd trimester TOP. These patients were analyzed in great detail regarding their history, examination and investigation. PGF2a was used extraamniotically. All patients expelled the fetus successfully. Four patients [8%] had retained placenta. No case of scar dehiscence or routine rupture was observed. The mean induction abortion interval was 10.25 hours. None of the patient required Hystostomy PGF2a is effective and safe in mid trimester TOP in patients even with uterine scar